Publications

  1. Waller MC, Bober JR, Nair NU, Beisel CL. Toward a genetic tool development pipeline for host-associated bacteria. Curr Opin Microbiol (accepted).
  2. Marshall R, Maxwell CS, Collins SP, Beisel CL, Noireaux V. Short DNA containing Chi sites enhances DNA stability and gene expression in E. coli cell-free transcription-translation systems. Biotechnol Bioeng (in press) pubmed article
  3. Leenay RT & Beisel CL. Deciphering, communicating, and engineering the CRISPR PAM. J Mol Biol (2017) 429(2):177-91. pubmed article
  4. Luo ML, Beisel CL. SBE Supplement: Synthetic Biology – Engineering Genes with CRISPR-Cas9. Chemical Engineering Progress. September 2106 issue. article
  5. Luo ML, Jackson RN, Denny SR, Tokmina-Lukaszewska M, Maksimchuk KR, Lin W, Bothner B, Wiedenheft B, Beisel CL. The CRISPR RNA-guided surveillance complex in Escherichia coli accommodates extended RNA spacers. Nucleic Acids Res (2016) 44(15):7385-94 pubmed article
  6. Leenay RT, Maksimchuk KR, Slotkowski RA, Agrawal RN, Gomaa AA, Briner AE, Barrangou R#, Beisel CL#. Identifying and visualizing functional PAM diversity across CRISPR-Cas systems. Mol Cell (2016) 62(1):137-47 pubmed article
  7. Luo ML, Leenay RT, Beisel CL. Current and future prospects for CRISPR-based tools in bacteria. Biotechnol Bioeng (2016) 113(5):930-43. pubmed article
  8. Beisel CL & Afroz T. Rethinking the hierarchy of sugar utilization in bacteria. J Bacteriol (2015) 198(3):374-6 pubmed article
  9. Sun, W, Ji W, Hall JM, Hu Q, Wang C, Beisel CL#, Gu Z#. Efficient delivery of CRISPR-Cas9 for genome editing via self-assembled DNA nanoclews. Angew Chem Int Ed (2015) 54(41):12029-33 pubmed article See comment in Chemical & Engineering News, Genetic Engineering & Biotechnology NewsWRAL news
  10. Afroz T, Luo ML, Beisel CL. Impact of residual inducer on titratable expression systems. PLoS One (2015) 10(9):e0137421. pubmed article
  11. Luo, ML, Mullis AS, Leenay RT, Beisel CL. Repurposing endogenous Type I CRISPR-Cas systems for programmable gene repression. Nucleic Acids Res (2015) 43(1):674-81 pubmed article See comment in BD Accuri News
  12. Afroz T, Biliouris K, Boykin KE, Kaznessis Y, Beisel CL. Trade-offs in engineering sugar utilization pathways for titratable control. ACS Synth Biol (2015) 4(2):141-9. pubmed article
  13. Briner AE*, Donohoue PD*, Gomaa AA*, Selle K, Slorach EM, Nye CH, Haurwitz RE, Beisel CL#, May AP#, Barrangou R#Guide RNA functional modules direct Cas9 activity and orthogonality. Mol Cell (2014) 56:333-9. pubmed article See comment in Genetic Engineering & Biotechnology News
  14. Beisel CL, Gomaa AA, Barrangou R. A CRISPR design for next-generation antimicrobials. Genome Biol (2014) 15:516 pubmed article
  15. Gomaa AA, Klumpe HE, Luo ML, Selle K, Barrangou R, Beisel CL. Programmable removal of bacterial strains by use of genome-targeting CRISPR-Cas systems. mBio (2014) 5:e00928-13. pubmed article See comment in NatureNew York Times, Wired MagazineScienceNewsFaculty of 1000
  16. Afroz T*, Biliouris K*, Kaznessis Y, Beisel CL. Bacterial sugar utilization gives rise to distinct single-cell behaviours. Mol Microbiol (2014) 93:1093-1103. pubmed article See comment in Mol Microbiol
  17. Beisel CL, Bloom RJ, Smolke CD. Construction of ligand-responsive microRNAs that operate through inhibition of Drosha processing. Methods Mol Biol (2014) 1111:259-67. pubmed article
  18. Afroz T & Beisel CL. Understanding and exploiting feedback in synthetic biology. Chem Eng Sci (2013) 103:79-90. article
  19. Beisel CL, Updegrove TB, Janson BJ, Storz G. Multiple factors dictate target selection by Hfq-binding small RNAs. EMBO J (2012) 31:1961-74 pubmed article See comment in Faculty of 1000
  20. Beisel CL & Storz G. Discriminating tastes: physiological contributions of the Hfq-binding small RNA Spot 42 to catabolite repression. RNA Biol (2011) 8:1-5. pubmed article
  21. Beisel CL & Storz G. The base pairing RNA Spot 42 participates in a multi-output feedforward loop to help enact catabolite repression in Escherichia coliMol Cell (2011) 41:286-97. pubmed article See comment in Mol Cell
  22. Beisel CL, Chen, YY, Culler SJ, Hoff KG, Smolke CD. Design of small molecule-responsive microRNAs based on structural requirements for Drosha processing. Nucleic Acids Res (2011) 39(7):2981-94. pubmed article See comment in Faculty of 1000
  23. Beisel CL & Storz G. Base pairing small RNAs and their roles in global regulatory networks. FEMS Microbiol Rev (2010) 34(5):866-82. pubmed article See comment in FEMS Microbiol Rev
  24. Beisel CL & Smolke CD. Design principles for riboswitch function. PLoS Comput Biol (2009) 5(4): e1000363. pubmed article
  25. Bayer TS, Hoff KG, Beisel CL, Lee JJ, Smolke CD. Synthetic control of a fitness trade-off in yeast nitrogen metabolism. J Biol Eng (2009) 3:1. pubmed article
  26. Beisel CL, Bayer TS, Hoff KG, Smolke CD. Model-guided design of ligand-regulated RNAi for programmable control of gene expression. Mol Syst Biol (2008) 4:224. pubmed article See comment in Mol Syst Biol

* multiple first authors, # multiple corresponding authors